Predecessor of SARMs

Anabolic steroids have been circulating within the sports world for years. As fanatical athletes and bodybuilders started looking for means to increase the production of muscle mass, the use of steroids increased enormously within the sports world. Everyone tries to achieve the maximum and many athletes do not shy away from using tools to achieve this. Gradually it became increasingly clear what the adverse effects of steroids meant for the human body. The drugs are banned because of the harmful side effects that their use entails. There is a laundry list of potential side effects when using these drugs such as acne, hair loss, liver damage, increased breast development, reduced fertility and so on.

Origin of SARMs

During the search for medicines to keep people physically strong at an older age, SARMs were discovered. SARMs stands for Selective Androgen Receptor Modulator. These drugs target the androgen receptor, the cell component addressed by testosterone and other steroids. The first SARM to be discovered was Andarine and seemed to have fewer side effects than other steroids. But several years later, a new SARM called Ostarine was discovered. This seemed much more promising than its predecessor and was extensively tested. A 12-week study in men showed an increase in muscle mass, a decrease in fat mass and better performance. In the years that followed, many other SARMs were developed, including Testolone, Ibutamore, Ligandrol and Cardarine. Due to the competitive component of sport, the attraction to resources such as SARMs was great. The WADA decided to add SARMs to the doping list because it would not be in line with the guidelines. But this did not stop athletes from experimenting with the means. The interest in SARMs continued to grow and the number of positive tests among professional athletes only increased over the years. For example, SARMs are sold online in hundreds of online stores as research chemicals that are not intended for personal use. However, anyone can legally order these resources without any problems. In the Netherlands, the possession and use of SARMs is legal.

Side effects of SARMs

The hope of biochemists was that the 'foreign' structure of SARMs would prevent the conversion of testosterone to other hormones by the same enzymes that transform testosterone. Unfortunately, this has not turned out to be the case so far. Dozens of SARMs circulating on the market are associated with various side effects. These effects range from high blood pressure, hair loss, rash, impotence to even decrease in vision. For this reason, no SARMs have yet received the green light from human use agencies. The intensity of the side effects of SARMs can vary, but due to the experimental nature of the drugs, it is overdosed by many. In the studies on Ostarine, a dose of 3mg was used, while on some forums doses as high as 50mg have been reported. These amounts bring an increased risk of lower natural testosterone production in the body, which can have many consequences. The use of SARMs is therefore strongly discouraged by both governments and experts..

Natural alternatives

The search for tools for increasing muscle growth continues.

For example, several natural alternatives are being discovered for the use of steroids or SARMs. One of these is ecdysteroids, but in particular Turkesterone. These substances occur naturally in the Ajuga Turkestanica plant and have been used for years in Ayurvedic medicine for various purposes. Ecdysteroids are natural steroid-like substances that have powerful properties. The plant extracts have recently come to the attention because of the positive contribution they can make to the sports performance of athletes, especially bodybuilders. The ecdysteroids are seen as a safer alternative to the banned and harmful steroids and SARMs. The side effects that apply to steroids and SARMs are not reported with the use of ecdysteroids.

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